Andrewsarchus mongoliensis (Osborn 1924; middle Eocene, 45 mya; AMNH 20135; 83cm skull length) was traditionally considered a mesonychid, then an artiodactyl related to entelodonts and whales, Andrewsarchus is here recognized as a giant extinct elephant shrew, a type of leptictid, known from its skull only. Derived from a sister to Leptictis, Andrewsarchus was probably the last of its kind, based on its size. The post-crania is unknown, but based on phylogenetic bracketing. the hind limbs would have been more robust than the forelimbs.

Paratriisodon henanensis (Chow 1959; early Late Eocene) based on a partial mandible and palate was also originally considered a creodont, but here shares many traits with Andrewsarchus.

Harpagolestes macrocephalus (Worthman 1901; late Paleocene, 50 mya) was also originally considered a mesonychid. Here it nests between Sinonyx and Andrewsarchus. Like the former, the orbit is at mid length. Like the latter, the rostrum was straight with a high point just posterior the orbit. The fourth molar was a vestige. The zygomatic arch was robust. The exoccipitals extended far posterior to the rest of the occiput.